Neurotransmitter Transporters

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  • Guvacine hydrochloride

    Guvacine hydrochloride is a specific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. Learn More

    Starting at: $125.00

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  • CI 966 hydrochloride

    CI 966 hydrochloride is a selective inhibitor of the GABA transporter GAT-1 (IC50 values are 0.26 and 1.2 μM at cloned human and rat GAT-1 respectively). Learn More

    Starting at: $120.00

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  • (S)-SNAP 5114

    BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM), reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle. Learn More

    Starting at: $135.00

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  • NNC 05-2090 hydrochloride

    NNC 05-2090 hydrochloride is a GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Learn More

    Starting at: $140.00

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  • (±)-Nipecotic acid

    (±)-Nipecotic acid is a GABA uptake inhibitor with IC50 values of 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. Learn More

    Starting at: $56.00

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  • Tiagabine hydrochloride

    Tiagabine hydrochloride is a GABA uptake inhibitor (IC50 = 67 nM in vivo), which exhibits high affinity and selectivity for the GAT-1 GABA transporter. Learn More

    Starting at: $169.00

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  • NNC 711

    NNC 711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Learn More

    Starting at: $135.00

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  • (S)-Duloxetine hydrochloride

    (S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HTand NA reuptake respectively in cortical synaptosomes, which exhibits antidepressant and anxiolytic effects. Learn More

    Starting at: $45.00

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  • Escitalopram oxalate

    Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI) (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Learn More

    Starting at: $55.00

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  • Citalopram hydrobromide

    Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake with IC50 values of 1.8, 8800 and 41000 nM respectively. Learn More

    Starting at: $105.00

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  • Lofepramine

    Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine, which produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo. Learn More

    Starting at: $90.00

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  • Fluoxetine hydrochloride

    Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. It binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Learn More

    Starting at: $69.00

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  • Amitriptyline hydrochloride

    Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenalin uptake and also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Learn More

    Starting at: $32.00

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  • Dexfenfluramine hydrochloride

    Dexfenfluramine hydrochloride is an indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Learn More

    Starting at: $49.00

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  • WY 45233 succinate

    WY 45233 succinate is a serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Learn More

    Starting at: $149.00

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  • Zimelidine dihydrochloride

    Zimelidine dihydrochloride is a 5-HT re-uptake inhibitor that modulates nociception and induces hyperglycemia in vivo. Learn More

    Starting at: $45.00

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  • Paroxetine maleate

    Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter. Learn More

    Starting at: $90.00

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  • BTS 54-505 hydrochloride

    BTS 54-505 hydrochloride is a potently active primary amine metabolite of sibutramine. Learn More

    Starting at: $95.00

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  • Sertraline hydrochloride

    Sertraline hydrochloride is a potent, orally active selective serotonin re-uptake inhibitor (SSRI). Learn More

    Starting at: $109.00

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  • Indatraline hydrochloride

    Indatraline hydrochloride is a potent monoamine uptake inhibitor that inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET). Learn More

    Starting at: $95.00

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