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Ligand-gated Ion Channels
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L-701,324
L-701,324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor. Learn MoreStarting at: $95.00
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Mirtazapine
Mirtazapine is an antidepressant agent that enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters. Learn MoreStarting at: $85.00
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Amperozide hydrochloride
Amperozide hydrochloride is a typical antipsychotic that displays high affinity for 5-HT2 receptors and low affinity for D2 receptors. Learn MoreStarting at: $99.00
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DOB hydrochloride
DOB hydrochloride is a Selective 5-HT2 receptor agonist with Ki values of 0.44, 59, 69, 831 and 3700 nM for 5-HT2H, 5-HT2L, 5-HT2C, 5-HT1B and 5-HT1A receptors respectively. Learn MoreStarting at: $99.00
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Org 37684
Org 37684 is an agonist of 5-HT2 receptors, which exhibits a rank order of potency of 5-HT2C >5-HT2B >5-HT2A (pEC50 values are 8.17, 7.96 and 7.11 respectively, in transfected CHO-K1 cells). Learn MoreStarting at: $119.00
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Metergoline
Metergoline is an antagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-HT6 and high affinity for 5-HT7. Learn MoreStarting at: $50.00
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Cinanserin hydrochloride
Cinanserin hydrochloride is a 5-HT2 antagonist. Learn MoreStarting at: $90.00
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5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative is a precursor to the highly potent and selective ligand for the α4β2 nicotinic receptor, 5-Iodo-A-85380. Suitable for radioiodination. Learn MoreStarting at: $90.00
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Desformylflustrabromine hydrochloride
Desformylflustrabromine hydrochloride is a positive allosteric modulator of α4β2 nicotinic acetylcholine receptors (nAChRs) which selectively increases the ionic current through α4β2 in the presence of ACh. Learn MoreStarting at: $119.00
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Kynurenic acid
Kynurenic acid is a broad spectrum EAA antagonist. Putative GPR35 ligand. Learn MoreStarting at: $65.00
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γDGG
γDGG is a broad spectrum glutamate receptor antagonist. Learn MoreStarting at: $109.00
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D-Glutamic acid
D-Glutamic acid is an excitatory amino acid acting at NMDA receptors. Learn MoreStarting at: $49.00
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(RS)-4-Carboxyphenylglycine
(RS)-4-Carboxyphenylglycine is a broad spectrum EAA ligand. Learn MoreStarting at: $99.00
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D-AP4
D-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Learn MoreStarting at: $169.00
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3-pyr-Cytisine
3-pyr-Cytisine is a high affinity α4β2 partial agonist that exhibits antidepressant-like effects in mouse models of antidepressant efficacy. Learn MoreStarting at: $139.00
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5-Iodo-A-85380 dihydrochloride
5-Iodo-A-85380 dihydrochloride is a highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors, which activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α3β4, α7 and muscle nAChR receptors respectively. Learn MoreStarting at: $195.00
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TC 2559 difumarate
TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively), which displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Learn MoreStarting at: $130.00
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Kynurenic acid sodium salt
Kynurenic acid sodium salt is a sodium salt of kynurenic acid, and it is a broad spectrum EAA antagonist. Learn MoreStarting at: $79.00
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Sazetidine A dihydrochloride
Sazetidine A dihydrochloride is a subtype-selective α4β2 nicotinic acetylcholine receptor ligand (Ki values are 0.26 and 54 nM at α4β2 and α3β4 receptors respectively). Learn MoreStarting at: $135.00
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DL-AP4 Sodium salt
DL-AP4 Sodium salt is a sodium salt of the broad spectrum EAA ligand DL-AP4 . Learn MoreStarting at: $65.00
