Ligand-gated Ion Channels
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DL-AP5 Sodium salt
DL-AP5 Sodium salt is a sodium salt of DL-AP5. Potent NMDA antagonist. Learn MoreStarting at: $69.00
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5,7-Dichlorokynurenic acid
5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). Learn MoreStarting at: $65.00
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SDZ 220-040
SDZ 220-040 is a potent competitive antagonist at the NMDA receptor (pKi = 8.5). Learn MoreStarting at: $140.00
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D-Aspartic acid
Endogenous NMDA receptor agonist with similar activity to the L-isomer (L-aspartic acid). Learn MoreStarting at: $80.00
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AR-R 17779 hydrochloride
AR-R 17779 hydrochloride is a selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). Learn MoreStarting at: $140.00
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Co 101244 hydrochloride
Co 101244 hydrochloride is a novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Learn MoreStarting at: $119.00
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Ro 04-5595 hydrochloride
Ro 04-5595 hydrochloride is a selective antagonist for NR2B-containing NMDA receptors (Ki = 31 nM). Learn MoreStarting at: $129.00
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Ro 8-4304 hydrochloride
Ro 8-4304 hydrochloride is a NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors, which exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine. Learn MoreStarting at: $109.00
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CGP 78608 hydrochloride
CGP 78608 hydrochloride is a potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays > 500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 μM respectively). Learn MoreStarting at: $140.00
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ACBC
ACBC is a NMDA receptor partial agonist, acting at the glycine site of NR1. Learn MoreStarting at: $80.00
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Gavestinel
Gavestinel is a highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM), which displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo. Learn MoreStarting at: $100.00
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L-701,252
L-701,252 is an antagonist at the glycine-NMDA site (IC50 = 420 nM). Learn MoreStarting at: $95.00
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Arcaine sulfate
Arcaine sulfate is a NO synthase inhibitor, acting as a competitive inhibitor at the polyamine site. Learn MoreStarting at: $80.00
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CCMQ
CCMQ is used in conjunction with [3H]-homoquinolinic acid to characterize NR2B-containing NMDA receptors which selectively inhibits [3H]-homoquinolinic acid binding to non-NMDA sensitive sites. Learn MoreStarting at: $95.00
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(R)-4-Carboxyphenylglycine
(R)-4-Carboxyphenylglycine is a Moderately potent NMDA receptor antagonist. Learn MoreStarting at: $135.00
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LY 235959
LY 235959 is a competitive NMDA receptor antagonist. Learn MoreStarting at: $120.00
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(RS)-(Tetrazol-5-yl)glycine
(RS)-(Tetrazol-5-yl)glycine is a potent NMDA receptor agonist, approximately 20 times more active than NMDA. Learn MoreStarting at: $140.00
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L-689,560
L-689,560 is a very potent antagonist at the glycine-NMDA site. Learn MoreStarting at: $135.00
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Pentamidine isethionate
Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist. Learn MoreStarting at: $80.00
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(2R,3S)-Chlorpheg
(2R,3S)-Chlorpheg is a weakly active NMDA receptor antagonist. Learn MoreStarting at: $185.00