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Ligand-gated Ion Channels
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D-Serine
D-Serine is a glycine agonist at the NMDA receptor. L-Serine also available. Learn MoreStarting at: $79.00
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Spermine tetrahydrochloride
Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects. Learn MoreStarting at: $59.00
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SDZ 220-040
SDZ 220-040 is a potent competitive antagonist at the NMDA receptor (pKi = 8.5). Learn MoreStarting at: $140.00
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CGP 78608 hydrochloride
CGP 78608 hydrochloride is a potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays > 500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 μM respectively). Learn MoreStarting at: $140.00
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CGP 39551
CGP 39551 is a potent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Learn MoreStarting at: $115.00
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LY 235959
LY 235959 is a competitive NMDA receptor antagonist. Learn MoreStarting at: $120.00
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D-AP5
D-AP5 is a competitive NMDA antagonist. Learn MoreStarting at: $59.00
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L-AP5
L-AP5 is a NMDA antagonist and also an agonist at quisqualate-sensitized AP6 site. Learn MoreStarting at: $145.00
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DL-AP7
DL-AP7 is a phosphono NMDA antagonist. Learn MoreStarting at: $79.00
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HU 211
HU 211 is a NMDA antagonist (IC50 = 11 μM for inhibition of [3H]MK-801 binding to rat forebrain membranes), which exhibits beneficial effects in experimental models of multiple sclerosis, bacterial meningitis, septic shock, epilepsy, and traumatic and ischemic brain injury. Brain penetrant. Learn MoreStarting at: $270.00
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PPPA
PPPA is a competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively). Learn MoreStarting at: $130.00
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PMPA (NMDA antagonist)
PMPA (NMDA antagonist) is a competitive NMDA receptor antagonist, which displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at NR2A, NR2B, NR2C and NR2D subunit-containing receptors respectively. Learn MoreStarting at: $125.00
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MG 624
MG 624 inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively. Learn MoreStarting at: $99.00
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N20C hydrochloride
N20C hydrochloride is a selective, non-competitive NMDA receptor antagonist that binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+ influx. Learn MoreStarting at: $99.00
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Remacemide hydrochloride
Remacemide hydrochloride is a non-competitive NMDA receptor antagonist which blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Learn MoreStarting at: $115.00
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L-Cysteinesulfinic acid
L-Cysteinesulfinic acid is a agonist at mGlu1a and mGlu5a subtypes expressed in clonal RGT cell lines. Also agonist at NMDA and PLD-coupled mGlu receptors. Learn MoreStarting at: $70.00
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D-AP7
D-AP7 is a more active form of AP7. Learn MoreStarting at: $179.00
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(RS)-CPP
(RS)-CPP is a potent NMDA antagonist. Separate isomer (R)-CPP also available. Learn MoreStarting at: $129.00
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CCMI
CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR) that evokes positive modulation of acetylcholine (ACh)-induced EC5 currents. Learn MoreStarting at: $95.00
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LY 2087101
LY 2087101 is an allosteric potentiator of α7, α4β2 and α4β4 nAChRs. Learn MoreStarting at: $125.00
