Ligand-gated Ion Channels

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  • (RS)-CPP

    (RS)-CPP is a potent NMDA antagonist. Separate isomer (R)-CPP also available. Learn More

    Starting at: $129.00

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  • CGS 19755

    CGS 19755 is a potent, competitive NMDA receptor antagonist. Learn More

    Starting at: $129.00

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  • L-Cysteinesulfinic acid

    L-Cysteinesulfinic acid is a agonist at mGlu1a and mGlu5a subtypes expressed in clonal RGT cell lines. Also agonist at NMDA and PLD-coupled mGlu receptors. Learn More

    Starting at: $70.00

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  • Remacemide hydrochloride

    Remacemide hydrochloride is a non-competitive NMDA receptor antagonist which blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Learn More

    Starting at: $115.00

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  • (S)-(-)-HA-966

    (S)-(-)-HA-966 is a possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. Learn More

    Starting at: $95.00

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  • HU 211

    HU 211 is a NMDA antagonist (IC50 = 11 μM for inhibition of [3H]MK-801 binding to rat forebrain membranes), which exhibits beneficial effects in experimental models of multiple sclerosis, bacterial meningitis, septic shock, epilepsy, and traumatic and ischemic brain injury. Brain penetrant. Learn More

    Starting at: $270.00

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  • PPPA

    PPPA is a competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively). Learn More

    Starting at: $130.00

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  • PMPA (NMDA antagonist)

    PMPA (NMDA antagonist) is a competitive NMDA receptor antagonist, which displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at NR2A, NR2B, NR2C and NR2D subunit-containing receptors respectively. Learn More

    Starting at: $125.00

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  • D-CPP-ene

    D-CPP-ene is a potent and competitive NMDA antagonist (Ki = 40 nM). Learn More

    Starting at: $270.00

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  • 5,7-Dichlorokynurenic acid sodium salt

    Sodium salt of 5,7-Dichlorokynurenic acid, a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). Learn More

    Starting at: $65.00

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  • Eliprodil

    Eliprodil is a non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Learn More

    Starting at: $90.00

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  • MNI-caged-NMDA

    MNI-caged-NMDA is a NMDA caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Learn More

    Starting at: $175.00

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  • QNZ 46

    QNZ 46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Learn More

    Starting at: $130.00

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  • (R)-(+)-HA-966

    (R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor. Learn More

    Starting at: $95.00

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  • LY 233053

    LY 233053 is a competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM, and nhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats. Learn More

    Starting at: $65.00

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  • (R)-CPP

    (R)-CPP is a highly potent NMDA antagonist, which shows some selectivity for NR2A-containing receptors (Ki values are 0.041, 0.27, 0.63 and 1.99 μM for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively). Learn More

    Starting at: $245.00

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  • CGP 37849

    CGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Learn More

    Starting at: $115.00

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  • CGP 39551

    CGP 39551 is a potent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Learn More

    Starting at: $115.00

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  • N-(4-Hydroxyphenylacetyl)spermine

    N-(4-Hydroxyphenylacetyl)spermine is a wasp toxin analog, which has been reported to be selective for NMDA receptors in mammalian CNS. Learn More

    Starting at: $125.00

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  • DL-AP5 Sodium salt

    DL-AP5 Sodium salt is a sodium salt of DL-AP5. Potent NMDA antagonist. Learn More

    Starting at: $69.00

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