You have no items in your shopping cart.
Kinases
-
DMNB
DMNB is an inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Learn MoreStarting at: $45.00
-
TCS 2002
TCS 2002 is a potent inhibitor of GSK-3β (IC50 = 35 nM), that inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain. Learn MoreStarting at: $129.00
-
TC-G 24
TC-G 24 is a potent GSK-3β inhibitor (IC50 = 17 nM), which displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Learn MoreStarting at: $135.00
-
BIO
BIO is a potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor that maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro and also promotes proliferation and dedifferentiation in cardiomyocytes. Learn MoreStarting at: $109.00
-
A 1070722
A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) which displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Learn MoreStarting at: $135.00
-
Indirubin-3'-oxime
ARL 67156 trisodium salt is a selective ecto-ATPase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively). Learn MoreStarting at: $110.00
-
3F8
L-755,507 is a potent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Learn MoreStarting at: $115.00
-
BIO-acetoxime
BIO-acetoxime is a selective GSK-3α/β inhibitor that induces Wnt signaling and inhibits CD8+ T cell effector differentiation. Learn MoreStarting at: $89.00
-
MeBIO
MeBIO is an Aryl hydrocarbon receptor (AhR) agonist that causes redistribution of AhR to the nucleus. Learn MoreStarting at: $119.00
-
PF 04885614
PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel), which exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Learn MoreStarting at: $125.00
-
PF 184
PF 184 is a Potent and selective IKKβ inhibitor (IC50 = 37 nM), which displays selectivity over 85 other kinases and inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress. Learn MoreStarting at: $195.00
-
Amlexanox
Amlexanox is a selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε. Learn MoreStarting at: $63.00
-
IKK 16
IKK 16 is a selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively), which inhibits TNF-α-stimulated IκB degradation and LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis. Learn MoreStarting at: $125.00
-
ACHP
ACHP is a IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively), which inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis. Learn MoreStarting at: $209.00
-
CZC 54252 hydrochloride
CZC 54252 hydrochloride is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Learn MoreStarting at: $145.00
-
2-Deoxy-D-glucose
2-Deoxy-D-glucose is a non-metabolizable glucose analog which inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Learn MoreStarting at: $80.00
-
ML 9 hydrochloride
ML 9 hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK). Ki values are 32, 4, and 54 μM for PKA, MLCK, and PKC respectively, which inhibits STIM1-plasma membrane interactions, and preventing store-operated Ca2+ entry (SOCE). Learn MoreStarting at: $90.00
-
Cyclapolin 9
Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM). Learn MoreStarting at: $105.00
-
KT 5720
KT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). Learn MoreStarting at: $165.00
-
RuBi-Dopa
RuBi-Dopa is a RuBi-caged dopamine; exhibits two-photon sensitivity, and enables non-invasive, optical activation of dopamine receptors with the spatial resolution of a single dendritic spine. Learn MoreStarting at: $199.00
