Kinases
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Mirin
Mirin is a mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. It also blocks homology-directed repair in vitro. Learn MoreStarting at: $95.00
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(-)-Terreic acid
Selective inhibitor of Bruton's tyrosine kinase (BTK), which inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Learn MoreStarting at: $155.00
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LFM-A13
LFM-A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK) that inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases. Learn MoreStarting at: $129.00
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(R)-DRF053 dihydrochloride
(R)-DRF053 dihydrochloride is a potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively), which also shown to inhibit amyloid-β production in N2A-APP695 cells. Learn MoreStarting at: $140.00
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PF 4800567 hydrochloride
PF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). Learn MoreStarting at: $125.00
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TBB
TBB is a cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Learn MoreStarting at: $65.00
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Olomoucine
Olomoucine is a cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase and selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM) and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase. Learn MoreStarting at: $99.00
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PHA 767491 hydrochloride
PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor with IC50 valuesof 10 and 34 nM respectively. Learn MoreStarting at: $99.00
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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NU 2058
This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Learn MoreStarting at: $100.00
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NU 6140
NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor which induces cell-cycle arrest at the G2-M phase. 10- to 36-fold more selective for cdk2-cyclin A over other cdks (IC50 = 0.41 μM for cdk2-cyclin A). Learn MoreStarting at: $139.00
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NSC 693868
NSC 693868 is an inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC50 values are 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively. Learn MoreStarting at: $139.00
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(R)-CR8
(R)-CR8 is an inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 0.13 μM for cdk1/cyclin B and cdk5/p25; and 0.6 μM for CK1). Learn MoreStarting at: $159.00
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Ryuvidine
Ryuvidine is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 6.0 μM at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC50 > 200 μM at cdk2/cyclin A). Learn MoreStarting at: $139.00
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Aminopurvalanol A
Aminopurvalanol A is a cell-permeable cyclin-dependent kinase inhibitor. Learn MoreStarting at: $140.00
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Purvalanol A
Purvalanol A is a cyclin-dependent kinase inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn MoreStarting at: $140.00
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NSC 625987
NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1) which displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). Learn MoreStarting at: $115.00
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Arcyriaflavin A
Arcyriaflavin A is a potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM), which inhibits human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM). Learn MoreStarting at: $135.00
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Dioctanoylglycol
Dioctanoylglycol is a specific inhibitor of diacylglycerol kinase. Learn MoreStarting at: $109.00
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KU 0060648
KU 0060648 is a dual, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and PI 3-K. Learn MoreStarting at: $195.00