Kinases

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  • Mirin

    Mirin is a mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. It also blocks homology-directed repair in vitro. Learn More

    Starting at: $95.00

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  • (-)-Terreic acid

    Selective inhibitor of Bruton's tyrosine kinase (BTK), which inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Learn More

    Starting at: $155.00

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  • LFM-A13

    LFM-A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK) that inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases. Learn More

    Starting at: $129.00

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  • (R)-DRF053 dihydrochloride

    (R)-DRF053 dihydrochloride is a potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively), which also shown to inhibit amyloid-β production in N2A-APP695 cells. Learn More

    Starting at: $140.00

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  • PF 4800567 hydrochloride

    PF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). Learn More

    Starting at: $125.00

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  • TBB

    TBB is a cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Learn More

    Starting at: $65.00

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  • Olomoucine

    Olomoucine is a cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase and selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM) and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase. Learn More

    Starting at: $99.00

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  • PHA 767491 hydrochloride

    PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor with IC50 valuesof 10 and 34 nM respectively. Learn More

    Starting at: $99.00

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  • Ro 3306

    Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn More

    Starting at: $139.00

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  • NU 2058

    This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Learn More

    Starting at: $100.00

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  • NU 6140

    NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor which induces cell-cycle arrest at the G2-M phase. 10- to 36-fold more selective for cdk2-cyclin A over other cdks (IC50 = 0.41 μM for cdk2-cyclin A). Learn More

    Starting at: $139.00

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  • NSC 693868

    NSC 693868 is an inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC50 values are 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively. Learn More

    Starting at: $139.00

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  • (R)-CR8

    (R)-CR8 is an inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 0.13 μM for cdk1/cyclin B and cdk5/p25; and 0.6 μM for CK1). Learn More

    Starting at: $159.00

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  • Ryuvidine

    Ryuvidine is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 6.0 μM at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC50 > 200 μM at cdk2/cyclin A). Learn More

    Starting at: $139.00

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  • Aminopurvalanol A

    Aminopurvalanol A is a cell-permeable cyclin-dependent kinase inhibitor. Learn More

    Starting at: $140.00

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  • Purvalanol A

    Purvalanol A is a cyclin-dependent kinase inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn More

    Starting at: $140.00

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  • NSC 625987

    NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1) which displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). Learn More

    Starting at: $115.00

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  • Arcyriaflavin A

    Arcyriaflavin A is a potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM), which inhibits human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM). Learn More

    Starting at: $135.00

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  • Dioctanoylglycol

    Dioctanoylglycol is a specific inhibitor of diacylglycerol kinase. Learn More

    Starting at: $109.00

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  • KU 0060648

    KU 0060648 is a dual, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and PI 3-K. Learn More

    Starting at: $195.00

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