Ion Channels
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Norketamine hydrochloride
Norketamine hydrochloride is a major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Learn MoreStarting at: $99.00
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Synthalin sulfate
Synthalin sulfate is an effective non-competitive NMDA receptor antagonist in vivo and in vitro. Learn MoreStarting at: $85.00
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TCS 46b
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively), whih potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration. Learn MoreStarting at: $109.00
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S 24795
S 24795 is a partial agonist of α7 nAChR, which improves mnemonic function in aged mice for the treatment of aging-related memory disturbances and displays more efficient memory-enhancing effects than memantine in Alzheimer's disease mouse models. Learn MoreStarting at: $90.00
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Spermine tetrahydrochloride
Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects. Learn MoreStarting at: $59.00
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D-Serine
D-Serine is a glycine agonist at the NMDA receptor. L-Serine also available. Learn MoreStarting at: $79.00
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DMAB-anabaseine dihydrochloride
DMAB-anabaseine dihydrochloride is a partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Learn MoreStarting at: $119.00
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Spermidine trihydrochloride
Spermidine trihydrochloride binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801. Learn MoreStarting at: $65.00
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(S)-(+)-Ketamine hydrochloride
(S)-(+)-Ketamine hydrochloride is a NMDA receptor antagonist, which displays neuroprotective efficacy in vitro. Learn MoreStarting at: $85.00
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Glycine
Glycine acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Learn MoreStarting at: $33.00
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L-Aspartic acid
L-Aspartic acid is an endogenous NMDA receptor agonist. Learn MoreStarting at: $32.00
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D-AP5
D-AP5 is a competitive NMDA antagonist. Learn MoreStarting at: $59.00
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D-AP7
D-AP7 is a more active form of AP7. Learn MoreStarting at: $179.00
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MNI-caged-D-aspartate
MNI-caged-D-aspartate is a D-aspartate caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Learn MoreStarting at: $149.00
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A 844606
A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist with EC50 values of 1.4 and 2.2 μM at human and rat receptors respectively. Learn MoreStarting at: $129.00
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SEN 12333
SEN 12333 is a α7 nicotinic acetylcholine receptor (nAChR) agonist that displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs with an IC50 value of 8.5 μM. Learn MoreStarting at: $125.00
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Quinolinic acid
Quinolinic acid is an endogenous NMDA agonist and transmitter candidate. Learn MoreStarting at: $59.00
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LY 2087101
LY 2087101 is an allosteric potentiator of α7, α4β2 and α4β4 nAChRs. Learn MoreStarting at: $125.00
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CCMI
CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR) that evokes positive modulation of acetylcholine (ACh)-induced EC5 currents. Learn MoreStarting at: $95.00
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L-AP5
L-AP5 is a NMDA antagonist and also an agonist at quisqualate-sensitized AP6 site. Learn MoreStarting at: $145.00