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Ion Channels
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(R)-(+)-Bay K 8644
(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Learn MoreStarting at: $189.00
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(S)-(-)-Bay K 8644
(S)-(-)-Bay K 8644 is a L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo. Learn MoreStarting at: $199.00
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RN 1734
RN 1734 is a selective TRPV4 antagonist with IC50 values of 2.3, 5.9 and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4 receptors respectively. Learn MoreStarting at: $95.00
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Benidipine hydrochloride
Benidipine hydrochloride is an orally active antihypertensive agent that inhibits L-, N- and T-type Ca2+ channels and also inhibits aldosterone-induced mineralocorticoid receptor activation. Learn MoreStarting at: $109.00
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HC 067047
HC 067047 is a potent and selective TRPV4 antagonist that reversibly inhibits currents through mouse, human and rat TRPV4 orthologs. Learn MoreStarting at: $139.00
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JNJ 303
JNJ 303 is a potent IKs blocker with an IC50 of 64 nM. Learn MoreStarting at: $125.00
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6-Iodonordihydrocapsaicin
6-Iodonordihydrocapsaicin is a potent competitive vanilloid TRPV1 (VR1) receptor antagonist that inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro. Learn MoreStarting at: $115.00
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RuBi-4AP
RuBi-4AP is a water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Learn MoreStarting at: $119.00
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A 784168
A 784168 is a potent TRPV1 antagonist with an IC50 value of 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin. Learn MoreStarting at: $139.00
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JNJ 17203212
JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that inhibits capsaicin- and H+-induced channel activation and exhibits antitussive and analgesic activity in vivo. Learn MoreStarting at: $119.00
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Bepridil hydrochloride
Bepridil hydrochloride is a calcium channel blocker that inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels. Learn MoreStarting at: $75.00
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Psora 4
Psora 4 is a potent KV1.3 channel blocker (EC50 = 3 nM) that preferentially binds the C-type inactivated state of the channel. Learn MoreStarting at: $145.00
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Veratridine
Veratridine is a Voltage-gated Na+ channel opener that increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Learn MoreStarting at: $79.00
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(±)-Bay K 8644
(±)-Bay K 8644 is a L-type Ca2+-channel activator with EC50 value of 17.3 nM. Learn MoreStarting at: $125.00
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NNC 55-0396 dihydrochloride
NNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker, which displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. Learn MoreStarting at: $199.00
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Mexiletine hydrochloride
Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Learn MoreStarting at: $49.00
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ML 218 hydrochloride
ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Learn MoreStarting at: $169.00
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Lercanidipine hydrochloride
Lercanidipine hydrochloride is a L-type Ca2+ channel blocker that displays higher vascular selectivity than felodipine Learn MoreStarting at: $75.00
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Sipatrigine
Sipatrigine is a blocker of voltage-dependent sodium channels (NaV) which inhibits glutamate release and displays neuroprotective activity in rat models of cerebral ischemia. Learn MoreStarting at: $145.00
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A 887826
A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Learn MoreStarting at: $135.00
