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Ion Channels
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ZD 7288
ZD 7288 is a sino-atrial node function modulator which blocks the hyperpolarization activated cation current If (HCN channel). Learn MoreStarting at: $105.00
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Quinidine
Quinidine reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP). Learn MoreStarting at: $19.00
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TRO 19622
TRO 19622 is a neuroprotective and neuroregenerative compound, which binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein. Learn MoreStarting at: $75.00
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4,4-Pentamethylenepiperidine hydrochloride
4,4-Pentamethylenepiperidine hydrochloride is a M2 proton channel blocker (IC50 = 0.92 μM) which inhibits influenza virus M2 protein (AM2). Learn MoreStarting at: $80.00
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LOE 908 hydrochloride
LOE 908 hydrochloride is a broad spectrum cation channel blocker, which inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+ and K+ channels. Learn MoreStarting at: $110.00
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Zatebradine hydrochloride
Zatebradine hydrochloride is a bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells and Purkinje fibres. Learn MoreStarting at: $109.00
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Ibutilide hemifumarate
Ibutilide hemifumarate is a class III antiarrhythmic which blocks the rapid component of delayed rectifier K+ current (IKr), hERG channels and L-type Ca2+ channels. Learn MoreStarting at: $85.00
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EIPA
EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM), which inhibits the Na+/H+ exchanger (NHE). Learn MoreStarting at: $65.00
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Phenamil
Phenamil is TRPP3 channel inhibitor (IC50 = 0.14 μM), which also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Learn MoreStarting at: $55.00
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ATPA
ATPA is a selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Learn MoreStarting at: $140.00
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Domoic acid
Domoic acid is more potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies. Learn MoreStarting at: $110.00
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MR 16728 hydrochloride
This analog of cetiedil stimulates the release of acetylcholine from synaptosomes. Learn MoreStarting at: $105.00
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SM-21 maleate
SM-21 maleate is a potent and selective σ2 antagonist with central effects following systemic administration. Learn MoreStarting at: $95.00
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PG-9 maleate
PG-9 maleate is a potent analgesic and nootropic agent. Increases release of acetylcholine. Learn MoreStarting at: $90.00
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SYM 2081
SYM 2081 is a potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Learn MoreStarting at: $139.00
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Kainic acid
Kainic acid is a selective agonist at kainate receptors. Potent excitant and neurotoxin. Learn MoreStarting at: $65.00
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UBP 301
UBP 301 is a potent kainate receptor antagonist that displays ~ 30-fold selectivity over AMPA receptors. Learn MoreStarting at: $139.00
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(S)-(-)-5-Iodowillardiine
(S)-(-)-5-Iodowillardiine demonstrates high affinity for the kainate receptor subtype hGluR5 (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6. Learn MoreStarting at: $135.00
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ACET
ACET is a potent and selective GluR5-containing kainate receptor antagonist that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Learn MoreStarting at: $275.00
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UBP 310
UBP 310 is a GLUK5 kainate receptor antagonist that also blocks recombinant homomeric GLUK7 receptors and displays 12,700-fold selectivity for GLUK5 over GLUK6. Learn MoreStarting at: $109.00
