Histamine Receptors

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  • (R)-(-)-α-Methylhistamine dihydrobromide

    (R)-(-)-α-Methylhistamine dihydrobromide is a very potent, high affinity H3 agonist that inhibits H3-mediated histamine synthesis and release in the CNS and stimulates H4-mediated eosinophil shape change. Learn More

    Starting at: $89.00

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  • (S)-(+)-α-Methylhistamine dihydrobromide

    (S)-(+)-α-Methylhistamine dihydrobromide is a less active enantiomer of H3 agonist R-(-)-α-methylhistamine. Learn More

    Starting at: $89.00

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  • BF 2649 hydrochloride

    BF 2649 hydrochloride is a histamine H3 receptor inverse agonist and antagonist that exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Learn More

    Starting at: $105.00

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  • Immepip dihydrobromide

    Phorbol 12-myristate 13-acetate is an extensively used phorbol ester activator of protein kinase C; tumor promoter. Learn More

    Starting at: $105.00

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  • JNJ 5207852 dihydrochloride

    JNJ 5207852 dihydrochloride is a high affinity histamine H3 receptor neutral antagonist (pKi values are 8.9 and 9.2 in rat and human respectively). Learn More

    Starting at: $120.00

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  • Impentamine dihydrobromide

    Impentamine dihydrobromide is a potent and highly selective histamine H3 receptor antagonist (pA2 = 8.4); displays > 30000-fold selectivity over H1 and H2 receptors. Learn More

    Starting at: $99.00

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  • Thioperamide

    Thioperamide is a potent histamine H3 and H4 antagonist/inverse agonist, which blocks eosinophil shape change (IC50 = 1.4 μM) and chemotaxis (IC50 = 519 nM) induced by histamine. Learn More

    Starting at: $90.00

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  • Iodophenpropit dihydrobromide

    Iodophenpropit dihydrobromide is a selective H3 antagonist with high affinity (KD = 0.3 nM). Learn More

    Starting at: $110.00

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  • Clobenpropit dihydrobromide

    Clobenpropit dihydrobromide is an extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93), which displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM. Learn More

    Starting at: $115.00

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  • Methimepip dihydrobromide

    Methimepip dihydrobromide is an extremely selective histamine H3 receptor agonist (pKi values are 9.0, 5.7, < 5.0 and < 5.0 for hH3, hH4, hH1 and hH2 receptors respectively). Learn More

    Starting at: $120.00

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  • GT 2016

    GT 2016 is a high affinity H3 receptor antagonist (Ki = 43.8 nM) which displays selectivity against H1 and H2 receptors (IC50 >10 μM). Increases the release of histamine in the cerebral cortex. Learn More

    Starting at: $115.00

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  • Proxyfan oxalate

    Proxyfan oxalate is a high affinity histamine H3 receptor ligand (pKi = 8.62) that acts as a protean agonist at recombinant and native receptors. Learn More

    Starting at: $95.00

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  • ROS 234 dioxalate

    ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Learn More

    Starting at: $95.00

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  • Imetit dihydrobromide

    Imetit dihydrobromide is an extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively), which induces shape change in eosinophils with an EC50 of 25 nM. Learn More

    Starting at: $90.00

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  • VUF 8430 dihydrobromide

    VUF 8430 dihydrobromide is a high affinity (pKi = 7.5), potent histamine H4 receptor full agonist (pEC50 = 7.3). Displays moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors. Learn More

    Starting at: $109.00

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  • VUF 10460

    VUF 10460 is a selective histamine H4 receptor agonist which displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22). Learn More

    Starting at: $129.00

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  • A 987306

    A 987306 is a potent histamine H4 receptor antagonist (pKi values are 8.24 and 8.47 in human and rat H4 receptors respectively), which blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42 μmol/kg, ip). Learn More

    Starting at: $140.00

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  • 4-Methylhistamine dihydrochloride

    4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes. Learn More

    Starting at: $139.00

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  • JNJ 10191584 maleate

    JNJ 10191584 maleate is a highly selective histamine H4 receptor silent antagonist that inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Learn More

    Starting at: $99.00

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