Hedgehog Signaling

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  • Ciliobrevin A

    Ciliobrevin A is a hedgehog (Hh) pathway antagonist which blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Learn More

    Starting at: $119.00

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  • U 18666A

    U 18666A is an inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Learn More

    Starting at: $139.00

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  • SANT-2

    SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM), which displays allosteric binding characteristics similar to SANT-1. Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively). Learn More

    Starting at: $139.00

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  • AY 9944 dihydrochloride

    AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms, which inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. Learn More

    Starting at: $119.00

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  • Jervine

    Jervine is an inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM), which binds directly to Smoothened (Smo), and inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Learn More

    Starting at: $159.00

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  • 20(S)-Hydroxycholesterol

    20(S)-Hydroxycholesterol is a allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein that activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). Learn More
  • HPI 1

    HPI 1, a Hedgehog (Hh) signaling inhibitor, inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells with IC50 values of 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation. Learn More

    Starting at: $129.00

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7 Item(s)

per page