Glutamate (Metabotropic) Group III Receptors
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Z-Cyclopentyl-AP4
Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. And selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Learn MoreStarting at: $129.00
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MSOP
MSOP is a selective group III metabotropic glutamate receptor antagonist that displays an apparent KDof 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Learn MoreStarting at: $138.00
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VU 0364770
VU 0364770 is a positive allosteric modulator at mGlu4 receptors with EC50 of 290 nM in mGlu4-expressing HEK 293 cells that prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Learn MoreStarting at: $109.00
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Cinnabarinic acid
Cinnabarinic acid is a mGlu4 receptor agonist that activates mGlu4 receptors in transiently transfected HEK293 cells, decreases cAMP levels in native cultured cerebellar granule cells and also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Learn MoreStarting at: $129.00
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MPPG
MTPG is a group II/group III metabotropic glutamate receptor antagonist, showing selectivity for group II in electrophysiological studies. Learn MoreStarting at: $135.00
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MMPIP hydrochloride
MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist, which inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Learn MoreStarting at: $65.00
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O-Phospho-L-serine
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4, which inhibits proliferation and enhances neuronal differentiation in progenitor cells. Learn MoreStarting at: $59.00
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UBP1112
UBP1112 is a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors). Learn MoreStarting at: $139.00
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L-AP4
L-AP4 is a selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Learn MoreStarting at: $60.00
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(S)-3,4-DCPG
(S)-3,4-DCPG is a potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7, which increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Learn MoreStarting at: $140.00
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ACPT-I
ACPT-I is an agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Learn MoreStarting at: $140.00
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CPPG
CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). Learn MoreStarting at: $115.00
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TC-N 22A
TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Learn MoreStarting at: $135.00
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VU 0155041 sodium salt
VU 0155041 sodium salt is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Learn MoreStarting at: $50.00
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NPEC-caged-(S)-3,4-DCPG
NPEC-caged-(S)-3,4-DCPG is a (S)-3,4-DCPG caged with the photosensitive 1-(2-nitrophenyl)ethoxycarbonyl group. Learn MoreStarting at: $215.00
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TCN 238
TCN 238 is a positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Learn MoreStarting at: $105.00
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(RS)-PPG
(RS)-PPG is a potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8. Learn MoreStarting at: $100.00
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VU 0155041
VU 0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Learn MoreStarting at: $120.00
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AMN 082 dihydrochloride
AMN 082 dihydrochloride is the first selective mGlu7 agonist, which potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Learn MoreStarting at: $89.00