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Glutamate (Metabotropic) Group II Receptors
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L-CCG-l
L-CCG-l is a potent group II metabotropic glutamate receptor agonist. Learn MoreStarting at: $185.00
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(E)-FeCP-oxindole
(E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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NPEC-caged-LY 379268
NPEC ((N)-1-(2-Nitrophenyl)ethoxycarbonyl) caged version of LY 379268, selective group II mGlu receptor agonist. Learn MoreStarting at: $345.00
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MNI 137
MNI 137 is a selective negative allosteric modulator of group II mGlu receptors with IC50 values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. Learn MoreStarting at: $139.00
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CBiPES hydrochloride
CBiPES hydrochloride is a selective positive allosteric modulator of the mGlu2 receptor with an IC50 value of 98.2 nM. Learn MoreStarting at: $115.00
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Xanthurenic acid
Xanthurenic acid attenuates cAMP formation in mouse cortical slices expressing mGlu2 and mGlu3 receptors. Learn MoreStarting at: $39.00
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(RS)-APICA
PNU 96415E is antipsychotic agent which displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Learn MoreStarting at: $105.00
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MTPG
RS 17053 hydrochloride is a α1A-adrenoceptor antagonist, with very high affinity for α1A receptors (pKi and pA2 estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α1B and α1D subtypes (pKi and pA2 estimates 7.7 - 7.8). Learn MoreStarting at: $135.00
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MSPG
MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices. Learn MoreStarting at: $135.00
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(2R,4R)-APDC
MSPG is a selatively non-selective antagonist of presynaptic mGlu receptors in neonatal rat spinal cord and adult rat cerebrocortical mGlu receptors. Learn MoreStarting at: $165.00
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MAP4
(S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Learn MoreStarting at: $135.00
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LY 487379 hydrochloride
LY 487379 hydrochloride is a positive allosteric modulator selective for mGlu2 receptors, which potentiates glutamate-stimulated [35S]GTPγS binding (EC50 values are 1.7 and > 10 μM for mGlu2 and mGlu3 receptors respectively). Learn MoreStarting at: $110.00
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Spaglumic acid
Spaglumic acid is the most abundant peptide neurotransmitter in the mammalian CNS. Learn MoreStarting at: $109.00
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Ro 64-5229
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist which inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM). Learn MoreStarting at: $140.00
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EGLU
EGLU is a selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist. Learn MoreStarting at: $110.00
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DCG IV
DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors. Learn MoreStarting at: $135.00
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CHIR 99021 trihydrochloride
CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021, a highly selective GSK-3 inhibitor. Learn MoreStarting at: $189.00
