GABA Receptors

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  • Ro 19-4603

    Ro 19-4603 is a benzodiazepine inverse agonist, which binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Learn More

    Starting at: $99.00

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  • GABA

    GABA is an endogenous inhibitory neurotransmitter. Learn More

    Starting at: $45.00

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  • CGP 35348

    CGP 35348 is a selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Learn More

    Starting at: $135.00

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  • CGP 46381

    CGP 46381 is a brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM). Learn More

    Starting at: $135.00

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  • CGP 36216 hydrochloride

    CGP 36216 hydrochloride is a selective GABAB antagonist, which displays activity at presynaptic receptors. Learn More

    Starting at: $130.00

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  • Saclofen

    Saclofen is a selective antagonist at GABAB receptors. Learn More

    Starting at: $115.00

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  • SKF 97541

    SKF 97541 is a very potent GABAB agonist, at least ten times more active than baclofen. Learn More

    Starting at: $115.00

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  • Pregnanolone

    Pregnanolone is a GABAA receptor positive allosteric modulator. Learn More

    Starting at: $95.00

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  • N-ArachidonylGABA

    N-ArachidonylGABA is a arachidonyl amino acid; first isolated from bovine brain. Learn More

    Starting at: $80.00

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  • L-655,708

    L-655,708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM), which displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Learn More

    Starting at: $105.00

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  • PHP 501 trifluoroacetate

    PHP 501 trifluoroacetate is a potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters. Learn More

    Starting at: $150.00

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  • rac BHFF

    rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively), which exhibits anxiolytic activity in vivo and is orally active. Learn More

    Starting at: $95.00

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  • Valerenic acid

    Valerenic acid is a positive allosteric modulator of GABAA receptors, which wdisplays preference for receptors containing β2 or β3 subunits and activates the receptor and also blocks the channel at high concentrations. Learn More

    Starting at: $85.00

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  • SR 95531 hydrobromide

    SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist, which acts as a low affinity glycine receptor antagonist and displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Learn More

    Starting at: $85.00

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  • CGS 20625

    CGS 20625 is a selective, partial agonist for the benzodiazepine binding site of the GABAA receptor which potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Learn More

    Starting at: $135.00

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  • (RS)-Baclofen

    (RS)-Baclofen is a selective GABAB receptor agonist, as well as a Skeletal muscle relaxant. Learn More

    Starting at: $65.00

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  • Phaclofen

    Phaclofen is a selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen. Learn More

    Starting at: $90.00

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  • Loreclezole hydrochloride

    Loreclezole hydrochloride is a subtype-selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.It also inhibits homomeric ρ1 GABAC receptors. Learn More

    Starting at: $125.00

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  • DMCM hydrochloride

    DMCM hydrochloride is a benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. Learn More

    Starting at: $110.00

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  • GBLD 345

    GBLD 345 is a high affinity benzodiazepine agonist (IC50 against diazepam = 1 nM). Learn More

    Starting at: $100.00

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