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FK 888
FK 888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors which inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.
Additional Info
Additional Info
| Catalog No. | ES1659 |
|---|---|
| CAS Number | 138449-07-7 |
| Formula | C36H36N4O4 |
| M. Wt | 588.69 |
| Purity | >98 % |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Chemical Name | (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide |
| Synonyms | N/A |
| Storage | Store at -20°C |
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