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Cyclin-Dependent Protein Kinase
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Olomoucine
Olomoucine is a cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase and selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM) and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase. Learn MoreStarting at: $99.00
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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NU 2058
This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Learn MoreStarting at: $100.00
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NU 6140
NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor which induces cell-cycle arrest at the G2-M phase. 10- to 36-fold more selective for cdk2-cyclin A over other cdks (IC50 = 0.41 μM for cdk2-cyclin A). Learn MoreStarting at: $139.00
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NSC 693868
NSC 693868 is an inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC50 values are 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively. Learn MoreStarting at: $139.00
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(R)-CR8
(R)-CR8 is an inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 0.13 μM for cdk1/cyclin B and cdk5/p25; and 0.6 μM for CK1). Learn MoreStarting at: $159.00
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Ryuvidine
Ryuvidine is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 6.0 μM at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC50 > 200 μM at cdk2/cyclin A). Learn MoreStarting at: $139.00
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Aminopurvalanol A
Aminopurvalanol A is a cell-permeable cyclin-dependent kinase inhibitor. Learn MoreStarting at: $140.00
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Purvalanol A
Purvalanol A is a cyclin-dependent kinase inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn MoreStarting at: $140.00
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NSC 625987
NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1) which displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). Learn MoreStarting at: $115.00
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Arcyriaflavin A
Arcyriaflavin A is a potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM), which inhibits human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM). Learn MoreStarting at: $135.00
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PHA 767491 hydrochloride
PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor with IC50 valuesof 10 and 34 nM respectively. Learn MoreStarting at: $99.00
