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AMG 548
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.
Additional Info
Additional Info
| Catalog No. | ES3713 |
|---|---|
| CAS Number | 864249-60-5 |
| Formula | C29H27N5O |
| M. Wt | 461.56 |
| Purity | >98 % |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Chemical Name | 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone |
| Synonyms | N/A |
| Storage | Store at -20°C |
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