mAChR

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  • Oxotremorine M

    Oxotremorine M is a muscarinic receptor agonist. Learn More

    Starting at: $69.00

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  • 5-Methylfurmethiodide

    5-Methylfurmethiodide is a potent muscarinic agonist. Learn More

    Starting at: $80.00

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  • Milameline hydrochloride

    Muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, hM2, hM3, hM4 and hM5 receptors respectively). Learn More

    Starting at: $95.00

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  • Oxotremorine sesquifumarate

    Oxotremorine sesquifumarate is a muscarinic agonist. Learn More

    Starting at: $55.00

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  • PTAC oxalate

    PTAC oxalate is a muscarinic receptor ligand, which displays partial agonist activity at M2 and M4 receptors; exhibits antagonist effects at M1, M3 and M5 receptors (Ki values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Learn More

    Starting at: $139.00

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  • W-84 dibromide

    W-84 dibromide stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Learn More

    Starting at: $98.00

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  • (+)-Muscarine iodide

    (+)-Muscarine iodide is a muscarinic acetylcholine receptor agonist; mimics the activity of acetylcholine. Learn More

    Starting at: $155.00

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  • Pilocarpine hydrochloride

    Pilocarpine hydrochloride is a muscarinic agonist. Learn More

    Starting at: $49.00

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  • VU 0365114

    VU 0365114 is a selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors). Learn More

    Starting at: $110.00

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  • VU 0238429

    VU 0238429 is a selective positive allosteric modulator of M5 receptors (EC50 values are 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively), which displays no activity at M2 and M4 receptors. Learn More

    Starting at: $90.00

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  • PD 102807

    PD 102807 is a selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively. Learn More

    Starting at: $140.00

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  • VU 152100

    VU 152100 is a selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM), which induces 21-fold shift in ACh potency at M4 receptor. Learn More

    Starting at: $119.00

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  • VU 10010

    VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptors that binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins. Learn More

    Starting at: $129.00

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  • J 104129 fumarate

    J 104129 fumarate is a potent M3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490 nM for human M3, M1 and M2 receptors respectively). Learn More

    Starting at: $139.00

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  • 4-DAMP

    4-DAMP is an antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors. Learn More

    Starting at: $90.00

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  • DAU 5884 hydrochloride

    DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. Learn More

    Starting at: $99.00

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  • Zamifenacin fumarate

    Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist (pKi values are 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors respectively), which inhibits gastrointestinal motility in vivo in the absence of cardiovascular effects. Learn More

    Starting at: $135.00

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  • AF-DX 116

    AF-DX 116 is a selective M2 muscarinic receptor antagonist. Ki values are 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively. Learn More

    Starting at: $105.00

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  • AF-DX 384

    AF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively). Learn More

    Starting at: $95.00

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  • (S)-(+)-Dimethindene maleate

    (S)-(+)-Dimethindene maleate is an enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Learn More

    Starting at: $135.00

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