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7-TM Receptors
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OPC 21268
OPC 21268 is a nonpeptide vasopressin V1 receptor antagonist, which displays greater affinity for rat V1 than human V1 (Ki values are 25 and 8800 nM respectively). Learn MoreStarting at: $150.00
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SR 49059
SR 49059 is a potent and selective non-peptide vasopressin V1A receptor antagonist; devoid of agonist activity, which displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors. Learn MoreStarting at: $225.00
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SB 611812
SB 611812 is an urotensin-II (UT) antagonist, which inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Learn MoreStarting at: $139.00
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SB 706375
SB 706375 is a high affinity, non-peptide antagonist of the urotensin-II (UT) receptor with high affinity for mammalian UT receptors, including human, mouse and rat (Ki values are 9.3, 19.1 and 20.7 nM respectively, in HEK293 cells expressing recombinant UT receptors). Learn MoreStarting at: $139.00
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(±)-AC 7954 hydrochloride
(±)-AC 7954 hydrochloride is a highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively). Learn MoreStarting at: $139.00
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SB 657510
SB 657510 is a selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively), which inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM). Learn MoreStarting at: $139.00
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Taltirelin
Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog which displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Learn MoreStarting at: $69.00
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(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively). Learn MoreStarting at: $85.00
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L-803,087 trifluoroacetate
L-803,087 trifluoroacetate is a potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Learn MoreStarting at: $209.00
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L-817,818
L-817,818 is a potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively which inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro. Learn MoreStarting at: $209.00
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NNC 26-9100
NNC 26-9100 is a somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Learn MoreStarting at: $155.00
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CYM 5442 hydrochloride
CYM 5442 hydrochloride is a potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM), which induces acute lymphopenia in mice. Learn MoreStarting at: $135.00
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TC-SP 14
TC-SP 14 is a potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Learn MoreStarting at: $135.00
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RP 001 hydrochloride
RP 001 hydrochloride is a potent agonist of S1P1 receptors (EC50 = 9 pM), which induces internalization and polyubiquitination of S1P1 in vitro. Learn MoreStarting at: $155.00
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CYM 50308
CYM 50308 is a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 values are 56 nM and 2100 nM for S1P4 and S1P5 receptors, respectively). Learn MoreStarting at: $150.00
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CYM 50260
CYM 50260 is a potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM) which displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM. Learn MoreStarting at: $110.00
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SEW 2871
SEW 2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Learn MoreStarting at: $69.00
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Sphingosine-1-phosphate
Sphingosine-1-phosphate endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization, which acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Learn MoreStarting at: $119.00
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CS 2100
CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 value of 4.0 nM. Learn MoreStarting at: $169.00
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CYM 5541
CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist that occupies a different space within the ligand binding pocket of S1P3 than S1P. Learn MoreStarting at: $115.00
