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5-HT2 Receptors
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SB 200646 hydrochloride
SB 200646 hydrochloride is a 5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Learn MoreStarting at: $135.00
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WAY 161503 hydrochloride
WAY 161503 hydrochloride is a potent and selective 5-HT2C receptor agonist with antidepressant effect following systemic administration in vivo. Learn MoreStarting at: $99.00
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MK 212 hydrochloride
MK 212 hydrochloride is a 5-HT receptor agonist with selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively). Learn MoreStarting at: $92.00
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WAY 629 hydrochloride
WAY 629 hydrochloride is a selective 5-HT2C agonist with Ki values of 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Learn MoreStarting at: $109.00
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Ro 60-0175 fumarate
Dibutyryl-cAMP, sodium salt is a cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Learn MoreStarting at: $105.00
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PNU 22394 hydrochloride
MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter. Learn MoreStarting at: $95.00
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SB 206553 hydrochloride
L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors. Learn MoreStarting at: $145.00
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Org 12962 hydrochloride
Org 12962 hydrochloride is a selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively), which displays antiaversive effects in a rat model of panic-like anxiety. Learn MoreStarting at: $105.00
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SB 243213 dihydrochloride
SB 243213 dihydrochloride is a selective 5-HT2C inverse agonist (pKb = 9.8), which displays selectivity over other 5-HT2 subtypes (pKi values are 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C respectively). Learn MoreStarting at: $140.00
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SB 221284
SB 221284 is a potent, selective 5-HT2C/2B receptor antagonist. pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively. Learn MoreStarting at: $110.00
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RS 102221 hydrochloride
RS 102221 hydrochloride is a potent and selective 5-HT2C antagonist (pKi = 8.7) which displays ~ 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and is > 100-fold selective over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors. Learn MoreStarting at: $110.00
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SB 242084
SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. Learn MoreStarting at: $140.00
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SB 228357
SB 228357 is a 5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively) which displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Learn MoreStarting at: $140.00
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1-Methylpsilocin
1-Methylpsilocin is a potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively) which displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Learn MoreStarting at: $95.00
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EMD 281014 hydrochloride
EMD 281014 hydrochloride is a selective 5-HT2A antagonist; displays high affinity for human 5-HT2A over 5-HT2C receptors (Ki values are 0.87 and 557 nM respectively). Learn MoreStarting at: $115.00
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Melperone hydrochloride
CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4), which competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast). Learn MoreStarting at: $65.00
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R-96544 hydrochloride
PPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Learn MoreStarting at: $120.00
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Mesulergine hydrochloride
Mesulergine hydrochloride is a 5-HT2A and 2C receptor antagonist and D2-like dopamine receptor partial agonist with antiprolactin and antiparkinsonian effects in vivo. Learn MoreStarting at: $129.00
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Spiperone hydrochloride
Spiperone hydrochloride is a 5-HT2A serotonin and selective D2-like dopamine receptor antagonist. Learn MoreStarting at: $99.00
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Nefazodone hydrochloride
Nefazodone hydrochloride is a serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Learn MoreStarting at: $89.00
