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5-HT Receptors
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Donitriptan hydrochloride
Donitriptan hydrochloride is a brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively) which inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Learn MoreStarting at: $105.00
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GR 55562 dihydrochloride
GR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes. Learn MoreStarting at: $120.00
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SB 224289 hydrochloride
SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2) which displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Learn MoreStarting at: $135.00
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SB 228357
SB 228357 is a 5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively) which displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Learn MoreStarting at: $140.00
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SB 242084
SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. Learn MoreStarting at: $140.00
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RS 102221 hydrochloride
RS 102221 hydrochloride is a potent and selective 5-HT2C antagonist (pKi = 8.7) which displays ~ 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and is > 100-fold selective over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors. Learn MoreStarting at: $110.00
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SB 221284
SB 221284 is a potent, selective 5-HT2C/2B receptor antagonist. pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively. Learn MoreStarting at: $110.00
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Mesulergine hydrochloride
Mesulergine hydrochloride is a 5-HT2A and 2C receptor antagonist and D2-like dopamine receptor partial agonist with antiprolactin and antiparkinsonian effects in vivo. Learn MoreStarting at: $129.00
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WAY 100635 maleate
WAY 100635 maleate is a potent, silent antagonist of 5-HT1A receptors with 100-fold selectivity for 5-HT1A over other 5-HT subtypes. It also has agonist activity at dopamine D4 receptors. Learn MoreStarting at: $119.00
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R-96544 hydrochloride
PPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Learn MoreStarting at: $120.00
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Melperone hydrochloride
CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4), which competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast). Learn MoreStarting at: $65.00
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8-Hydroxy-PIPAT oxalate
SCH 58261 is a potent and selective A2A adenosine receptor competitive antagonist (Ki = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively. Learn MoreStarting at: $120.00
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MM 77 dihydrochloride
This ligand has uniquely high affinity and selectivity for the D3 receptor. Learn MoreStarting at: $95.00
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Spiperone hydrochloride
Spiperone hydrochloride is a 5-HT2A serotonin and selective D2-like dopamine receptor antagonist. Learn MoreStarting at: $99.00
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8-Hydroxy-DPAT hydrobromide
8-Hydroxy-DPAT hydrobromide is a standard selective 5-HT1A agonist that reduces hippocampal 5-HT levels following systemic administration in rats in vivo. Learn MoreStarting at: $59.00
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(R)-(+)-8-Hydroxy-DPAT hydrobromide
(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT1A serotonin receptor agonist that reduces hippocampal 5-HT levels following systemic administration in rats in vivo. It is more active enantiomer of 8-Hydroxy-DPAT hydrobromide. Learn MoreStarting at: $109.00
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Nefazodone hydrochloride
Nefazodone hydrochloride is a serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Learn MoreStarting at: $89.00
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BP 554 maleate
BP 554 maleate is a selective 5-HT1A agonist. Learn MoreStarting at: $95.00
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Xaliproden hydrochloride
Xaliproden hydrochloride is an orally active, full agonist at 5-HT1A receptors that is > 300-fold selective over other 5-HT receptor subtypes with an IC50 value of > 650 nM. Learn MoreStarting at: $105.00
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TCB-2
TCB-2 is a high affinity 5-HT2A receptor agonist that potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors with an EC50 value of 36 nM. Learn MoreStarting at: $139.00
