5-HT Receptors

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  • CGS 12066B dimaleate

    CGS 12066B dimaleate is a 5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Learn More

    Starting at: $60.00

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  • CP 93129 dihydrochloride

    CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist. Learn More

    Starting at: $105.00

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  • CP 94253 hydrochloride

    CP 94253 hydrochloride is a potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Learn More

    Starting at: $140.00

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  • SB 200646 hydrochloride

    SB 200646 hydrochloride is a 5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Learn More

    Starting at: $135.00

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  • 1-Methylpsilocin

    1-Methylpsilocin is a potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively) which displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Learn More

    Starting at: $95.00

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  • Donitriptan hydrochloride

    Donitriptan hydrochloride is a brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively) which inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Learn More

    Starting at: $105.00

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  • GR 55562 dihydrochloride

    GR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes. Learn More

    Starting at: $120.00

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  • SB 224289 hydrochloride

    SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2) which displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Learn More

    Starting at: $135.00

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  • SB 228357

    SB 228357 is a 5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively) which displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Learn More

    Starting at: $140.00

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  • SB 242084

    SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. Learn More

    Starting at: $140.00

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  • RS 102221 hydrochloride

    RS 102221 hydrochloride is a potent and selective 5-HT2C antagonist (pKi = 8.7) which displays ~ 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and is > 100-fold selective over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors. Learn More

    Starting at: $110.00

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  • SB 221284

    SB 221284 is a potent, selective 5-HT2C/2B receptor antagonist. pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively. Learn More

    Starting at: $110.00

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  • SB 243213 dihydrochloride

    SB 243213 dihydrochloride is a selective 5-HT2C inverse agonist (pKb = 9.8), which displays selectivity over other 5-HT2 subtypes (pKi values are 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C respectively). Learn More

    Starting at: $140.00

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  • NAS-181

    NAS-181 is a potent, selective antagonist at the rat 5-HT1B receptor (Ki = 47 nM). Learn More

    Starting at: $155.00

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  • Org 12962 hydrochloride

    Org 12962 hydrochloride is a selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively), which displays antiaversive effects in a rat model of panic-like anxiety. Learn More

    Starting at: $105.00

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  • LY 393558

    LY 393558 is a dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Learn More

    Starting at: $139.00

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  • 5-Nonyloxytryptamine oxalate

    GR 159897 is a potent, selective, non-peptide, orally active neurokinin NK2 receptor antagonist , which inhibits NK2 receptor-mediated contraction of guinea pig trachea with a pA2 of 8.7. Learn More

    Starting at: $105.00

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  • SB 206553 hydrochloride

    L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors. Learn More

    Starting at: $145.00

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  • PNU 22394 hydrochloride

    MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter. Learn More

    Starting at: $95.00

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  • Ro 60-0175 fumarate

    Dibutyryl-cAMP, sodium salt is a cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Learn More

    Starting at: $105.00

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